Discovery of First-in-Class Small Molecule Inhibitors of Lymphocyte Activation Gene 3 (LAG-3)-Reference-Cited by-同舟云学术

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Discovery of First-in-Class Small Molecule Inhibitors of Lymphocyte Activation Gene 3 (LAG-3)

Published:2023-04-11 Issue:5 Volume:14 Page:629-635
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Abdel-Rahman Somaya A.¹²,Rehman Ashfaq Ur³,Gabr Moustafa T.¹^ORCID

Affiliation:

1. Department of Radiology, Molecular Imaging Innovations Institute (MI3), Weill Cornell Medicine, New York, New York 10065, United States

2. Department of Medicinal Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt

3. Department of Molecular Biology and Biochemistry, University of California, Irvine, Irvine, California 92697, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.3c00054

Reference43 articles.

1. A decade of checkpoint blockade immunotherapy in melanoma: understanding the molecular basis for immune sensitivity and resistance

2. The history and advances in cancer immunotherapy: understanding the characteristics of tumor-infiltrating immune cells and their therapeutic implications

3. Immune Checkpoint Inhibitors in Cancer Therapy

4. Anti-PD-1 and Anti-CTLA-4 Therapies in Cancer: Mechanisms of Action, Efficacy, and Limitations

5. Current landscape and future of dual anti-CTLA4 and PD-1/PD-L1 blockade immunotherapy in cancer; lessons learned from clinical trials with melanoma and non-small cell lung cancer (NSCLC)

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1. Discovery of ICOS-targeted small molecules using affinity selection mass spectrometry screening;2024-08-07

2. From Virtual Screens to Cellular Target Engagement: New Small Molecule Ligands for the Immune Checkpoint LAG-3;2024-08-07

3. Design and Biophysical Characterization of Second-Generation Cyclic Peptide LAG-3 Inhibitors for Cancer Immunotherapy;2024-08-06

4. ImmunoPET imaging of LAG-3 expression in tumor microenvironment with⁶⁸Ga-labelled cyclic peptides tracers: from bench to bedside;Journal for ImmunoTherapy of Cancer;2024-07

5. Structure-Based Rational Design of Constrained Peptides as TIM-3 Inhibitors;ACS Medicinal Chemistry Letters;2024-05-28

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