PK/PD Disconnect Observed with a Reversible Endothelial Lipase Inhibitor
Author:
Affiliation:
1. Research and Development, Bristol-Myers Squibb, Princeton, New Jersey 08543, United States
Funder
Bristol-Myers Squibb
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.8b00138
Reference32 articles.
1. A novel endothelial-derived lipase that modulates HDL metabolism
2. Cloning of a Unique Lipase from Endothelial Cells Extends the Lipase Gene Family
3. Dose-Dependent Acceleration of High-Density Lipoprotein Catabolism by Endothelial Lipase
4. Scavenger Receptor BI-mediated Selective Uptake Is Required for the Remodeling of High Density Lipoprotein by Endothelial Lipase
5. Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism
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