Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype-Reference-Cited by-同舟云学术

Computer-Assisted Discovery and Structural Optimization of a Novel Retinoid X Receptor Agonist Chemotype

Published:2019-01-04 Issue:2 Volume:10 Page:203-208
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Heitel Pascal¹^ORCID,Gellrich Leonie¹,Kalinowsky Lena¹,Heering Jan²,Kaiser Astrid¹,Ohrndorf Julia¹,Proschak Ewgenij¹^ORCID,Merk Daniel¹^ORCID

Affiliation:

1. Institute of Pharmaceutical Chemistry, Goethe University Frankfurt, Max-von-Laue-Str. 9, 60438 Frankfurt, Germany

2. Project Group Translational Medicine and Pharmacology TMP, Fraunhofer Institute for Molecular Biology and Applied Ecology IME, Theodor-Stern-Kai 7, D-60596 Frankfurt, Germany

Funder

Deutsche Forschungsgemeinschaft

Else Kröner-Fresenius-Stiftung

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.8b00551

Reference19 articles.

1. International Union of Pharmacology. LXIII. Retinoid X Receptors

2. Retinoid X receptor ligands: a patent review (2007 – 2013)

3. Retinoid X receptor gamma signaling accelerates CNS remyelination

4. ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models

5. DrugBank screening revealed alitretinoin and bexarotene as liver X receptor modulators

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