Covalent Inhibitors of Plasmodium falciparum Glyceraldehyde 3-Phosphate Dehydrogenase with Antimalarial Activity in Vitro-Reference-Cited by-同舟云学术

Covalent Inhibitors of Plasmodium falciparum Glyceraldehyde 3-Phosphate Dehydrogenase with Antimalarial Activity in Vitro

Published:2019-02-20 Issue:4 Volume:10 Page:590-595
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Cullia Gregorio¹,Bruno Stefano²,Parapini Silvia³,Margiotta Marilena²,Tamborini Lucia¹,Pinto Andrea⁴^ORCID,Galbiati Andrea¹,Mozzarelli Andrea²^ORCID,Persico Marco⁵,Paladino Antonella⁶,Fattorusso Caterina⁵,Taramelli Donatella⁷,Conti Paola¹^ORCID

Affiliation:

1. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, Via Mangiagalli 25, 20133 Milano, Italy

2. Dipartimento di Scienze degli Alimenti e del Farmaco, Università degli Studi di Parma, Area Parco delle Scienze 23A, 43124 Parma, Italy

3. Dipartimento di Scienze Biomediche, Chirurgiche e Odontoiatriche, Università degli Studi di Milano, Via Pascal 36, 20133 Milano, Italy

4. Dipartimento di Scienze per gli Alimenti, la Nutrizione e l’Ambiente, Via Celoria 2, 20133 Milano, Italy

5. Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy

6. Istituto di Chimica del Riconoscimento Molecolare, Consiglio Nazionale delle Ricerche, Via M. Bianco 9, 20131 Milano, Italy

7. Dipartimento di Scienze Farmacologiche e Biomolecolari, Università degli Studi di Milano, Via Pascal 36, 20133 Milano, Italy

Funder

Universit?? degli Studi di Milano

Ministero dell'Istruzione, dell'Universit?? e della Ricerca

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.8b00592

Reference28 articles.

1. WHO. Malaria report 2017.

2. malERA: An updated research agenda for basic science and enabling technologies in malaria elimination and eradication

3. Exploiting Unique Structural and Functional Properties of Malarial Glycolytic Enzymes for Antimalarial Drug Development

4. Plasmodium falciparum: Stage-specific lactate production in synchronized cultures

5. d-Lactate production in erythrocytes infected with Plasmodium falciparum

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