Synthesis of 12-O-Mono- and Diglycosyl-oxystearates, a New Class of Agonists for the C-type Lectin Receptor Mincle
Author:
Affiliation:
1. Department of Natural Products Chemistry, Graduate School of Pharmaceutical Sciences, Kyushu University, Fukuoka 812-8582, Japan
2. Department of Molecular Immunology, Immunology Frontier Research Center, Osaka University, Osaka 565-0871, Japan
Funder
Ministry of Education, Culture, Sports, Science and Technology
Japan Society for the Promotion of Science
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.8b00413
Reference33 articles.
1. Cutting Edge: Mincle Is Essential for Recognition and Adjuvanticity of the Mycobacterial Cord Factor and its Synthetic Analog Trehalose-Dibehenate
2. Direct recognition of the mycobacterial glycolipid, trehalose dimycolate, by C-type lectin Mincle
3. Trehalose diester glycolipids are superior to the monoesters in binding to Mincle, activation of macrophages in vitro and adjuvant activity in vivo
4. Rational design of adjuvants targeting the C-type lectin Mincle
5. Sensing Lipids with Mincle: Structure and Function
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