MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate-Reference-Cited by-同舟云学术

MK-7622: A First-in-Class M1 Positive Allosteric Modulator Development Candidate

Published:2018-04-30 Issue:7 Volume:9 Page:652-656
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Beshore Douglas C.¹^ORCID,N. Di Marco Christina¹,Chang Ronald K.¹,Greshock Thomas J.¹,Ma Lei¹,Wittmann Marion¹,Seager Matthew A.¹,Koeplinger Kenneth A.¹,Thompson Charles D.¹,Fuerst Joy¹,Hartman George D.¹,Bilodeau Mark T.¹,Ray William J.¹,Kuduk Scott D.¹

Affiliation:

1. MRL, Merck & Co., Inc., Kenilworth, New Jersey 07033, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.8b00095

Reference24 articles.

1. Abnormalities of neural circuitry in Alzheimer's disease: Hippocampus and cortical cholinergic innervation

2. The molecular basis of muscarinic receptor diversity

3. Muscarinic acetylcholine receptor expression in memory circuits: Implications for treatment of Alzheimer disease

4. Muscarinic acetylcholine receptors as CNS drug targets

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