Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors-Reference-Cited by-同舟云学术

Discovery of a Series of 3-Cinnoline Carboxamides as Orally Bioavailable, Highly Potent, and Selective ATM Inhibitors

Published:2018-07-13 Issue:8 Volume:9 Page:809-814
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Barlaam Bernard¹^ORCID,Cadogan Elaine¹,Campbell Andrew²,Colclough Nicola¹,Dishington Allan²,Durant Stephen¹,Goldberg Kristin¹,Hassall Lorraine A.²,Hughes Gareth D.¹,MacFaul Philip A.²,McGuire Thomas M.¹,Pass Martin¹,Patel Anil²,Pearson Stuart¹,Petersen Jens³,Pike Kurt G.¹^ORCID,Robb Graeme¹,Stratton Natalie⁴,Xin Guohong⁵,Zhai Baochang⁵

Affiliation:

1. Oncology, IMED Biotech Unit, AstraZeneca, Cambridge, U.K.

2. Oncology, IMED Biotech Unit, AstraZeneca, Macclesfield, U.K.

3. Discovery Sciences, IMED Biotech Unit, AstraZeneca, Gothenburg, Sweden

4. Discovery Sciences, IMED Biotech Unit, AstraZeneca, Cambridge, U.K.

5. Pharmaron Beijing Co., Ltd., 6 Taihe Road BDA, Beijing, P. R. China

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.8b00200