Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies-Reference-Cited by-同舟云学术

Novel Compounds Targeting the RNA-Binding Protein HuR. Structure-Based Design, Synthesis, and Interaction Studies

Published:2019-01-21 Issue:4 Volume:10 Page:615-620
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Della Volpe Serena¹,Nasti Rita¹,Queirolo Michele¹,Unver M. Yagiz²³,Jumde Varsha K.²³,Dömling Alexander⁴^ORCID,Vasile Francesca⁵,Potenza Donatella⁵,Ambrosio Francesca Alessandra⁶,Costa Giosué⁶^ORCID,Alcaro Stefano⁶,Zucal Chiara⁷,Provenzani Alessandro⁷^ORCID,Di Giacomo Marcello¹,Rossi Daniela¹,Hirsch Anna K. H.²³,Collina Simona¹^ORCID

Affiliation:

1. Department of Drug Sciences, Medicinal Chemistry and Technology Section, University of Pavia, Via Taramelli 12, 27100 Pavia, Italy

2. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS) - Helmholtz Centre for Infection Research (HZI), Department of Drug Design and Optimization and Department of Pharmacy, Saarland University, Campus Building E8.1, 66123 Saarbrücken, Germany

3. Stratingh Institute for Chemistry, University of Groningen, Nijenborgh 7, NL-9747 AG, Groningen, The Netherlands

4. Department of Drug Design, University of Groningen, A. Deusinglaan 1, Groningen, 9713 AV, The Netherlands

5. Department of Chemistry, University of Milan, Via Golgi 19, 20133 Milano, Italy

6. Department of Health Sciences, University “Magna Græcia” of Catanzaro, Viale Europa, 88100, Catanzaro, Italy

7. Department of CIBIO, University of Trento, Via Sommarive 9, 38123 Povo, TN, Italy

Funder

Helmholtz-Gemeinschaft

Associazione Italiana per la Ricerca sul Cancro

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.8b00600

Reference39 articles.

1. The complex world of post-transcriptional mechanisms: is their deregulation a common link for diseases? Focus on ELAV-like RNA-binding proteins

2. The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells

3. RNA-binding proteins as molecular links between cancer and neurodegeneration

4. Protein–RNA interactions: new genomic technologies and perspectives

5. RNA binding proteins: a common denominator of neuronal function and dysfunction

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