Tetrahydroisoquinoline CXCR4 Antagonists Adopt a Hybrid Binding Mode within the Peptide Subpocket of the CXCR4 Receptor-Reference-Cited by-同舟云学术

Tetrahydroisoquinoline CXCR4 Antagonists Adopt a Hybrid Binding Mode within the Peptide Subpocket of the CXCR4 Receptor

Published:2018-11-30 Issue:1 Volume:10 Page:67-73
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Katzman Brooke M.¹,Cox Bryan D.¹,Prosser Anthony R.¹,Alcaraz Ana A.¹,Murat Brigitte²,Héroux Madeleine²,Tebben Andrew³,Zhang Yong³^ORCID,Schroeder Gretchen M.³,Snyder James P.¹,Wilson Lawrence J.¹^ORCID,Liotta Dennis C.¹^ORCID

Affiliation:

1. Department of Chemistry, Emory University, 1521 Dickey Drive, Atlanta, Georgia 30322, United States

2. Medicinal Chemistry platform, Institute for Research in Immunology and Cancer (IRIC), Université de Montréal, Montréal, Québec H3C 3J7, Canada

3. Bristol-Myers Squibb R&D, US Route 206 and Province Line Road, Princeton, New Jersey 08543-4000, United States

Funder

Bristol-Myers Squibb

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.8b00441

Reference24 articles.

1. Cancer and the chemokine network

2. The CXC chemokine SDF-1 is the ligand for LESTR/fusin and prevents infection by T-cell-line-adapted HIV-1

3. Function of the chemokine receptor CXCR4 in haematopoiesis and in cerebellar development

4. Emergence of small-molecule CXCR4 antagonists as novel immune and hematopoietic system regulatory agents

5. CXCR4 antagonists: targeting the microenvironment in leukemia and other cancers

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