New in Vitro Assay Measuring Direct Interaction of Nonsense Suppressors with the Eukaryotic Protein Synthesis Machinery-Reference-Cited by-同舟云学术

New in Vitro Assay Measuring Direct Interaction of Nonsense Suppressors with the Eukaryotic Protein Synthesis Machinery

Published:2018-11-21 Issue:12 Volume:9 Page:1285-1291
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Ng Martin Y.¹,Zhang Haibo¹,Weil Amy¹,Singh Vijay²,Jamiolkowski Ryan²,Baradaran-Heravi Alireza³,Roberge Michel³,Jacobson Allan⁴,Friesen Westley⁵,Welch Ellen⁵,Goldman Yale E.²,Cooperman Barry S.¹^ORCID

Affiliation:

1. Department of Chemistry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States

2. Department of Physiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, United States

3. Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, BC, Canada V6T 1Z3

4. Department of Microbiology and Physiological Systems, University of Massachusetts Medical School, Worcester, Massachusetts 01655, United States

5. PTC Therapeutics, 100 Corporate Court, South Plainfield, New Jersey 07080, United States

Funder

Cystic Fibrosis Foundation

National Institute of General Medical Sciences

Michael Smith Foundation for Health Research

Orphan Disease Center, University of Pennsylvania

PTC Therapeutics

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.8b00472

Reference38 articles.

1. Genetic Code: The ‘Nonsense’ Triplets for Chain Termination and their Suppression

2. When proteins start to make sense: fine-tuning of aminoglycosides for PTC suppression therapy

3. Therapeutics Based on Stop Codon Readthrough

4. Production of β-globin and adult hemoglobin following G418 treatment of erythroid precursor cells from homozygous β039 thalassemia patients

5. A comparative evaluation of NB30, NB54 and PTC124 in translational read‐through efficacy for treatment of an USH1C nonsense mutation

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