Maximizing ER-α Degradation Maximizes Activity in a Tamoxifen-Resistant Breast Cancer Model: Identification of GDC-0927
Author:
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.8b00414
Reference13 articles.
1. Estrogen Receptors: Therapies Targeted to Receptor Subtypes
2. Estrogen Receptors as Therapeutic Targets in Breast Cancer
3. Pathways to tamoxifen resistance
4. Biological determinants of endocrine resistance in breast cancer
5. Fulvestrant - A Novel Endocrine Therapy for Breast Cancer
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3. An Open-label Phase I Study of GDC-0927 in Postmenopausal Women with Locally Advanced or Metastatic Estrogen Receptor–Positive Breast Cancer;Clinical Cancer Research;2023-06-01
4. Design, synthesis and biological evaluation of fluorinated selective estrogen receptor degraders (FSERDs) --- A promising strategy for advanced ER positive breast cancer;European Journal of Medicinal Chemistry;2023-05
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