Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes-Reference-Cited by-同舟云学术

Discovery of an Isothiazole-Based Phenylpropanoic Acid GPR120 Agonist as a Development Candidate for Type 2 Diabetes

Published:2017-08-02 Issue:9 Volume:8 Page:947-952
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Zhang Xuqing¹^ORCID,Cai Chaozhong¹,Sui Zhihua¹,Macielag Mark¹,Wang Yuanping¹,Yan Wen¹,Suckow Arthur¹,Hua Hong¹,Bell Austin¹,Haug Peter¹,Clapper Wilma¹,Jenkinson Celia¹,Gunnet Joseph¹,Leonard James¹,Murray William V.¹

Affiliation:

1. Cardiovascular and Metabolic Research, Janssen Research & Development, LLC, Welsh & McKean Roads, Box 776, Spring House, Pennsylvania 19477, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.7b00233

Reference20 articles.

1. Free fatty acids regulate gut incretin glucagon-like peptide-1 secretion through GPR120

2. Cloning, expression, and pharmacological characterization of the GPR120 free fatty acid receptor from cynomolgus monkey: Comparison with human GPR120 splice variants

3. Review: Free fatty acid receptors: emerging targets for treatment of diabetes and its complications

4. GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

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