Synthesis and Evaluation of a Linkable Functional Group-Equipped Analogue of the Epothilones-Reference-Cited by-同舟云学术

Synthesis and Evaluation of a Linkable Functional Group-Equipped Analogue of the Epothilones

Published:2017-05-04 Issue:7 Volume:8 Page:701-704
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Foley Corinne N.¹,Chen Liang-An¹,Sackett Dan L.²,Leighton James L.¹^ORCID

Affiliation:

1. Department of Chemistry, Columbia University, New York, New York 10027, United States

2. Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892, United States

Funder

National Institute of General Medical Sciences

Eunice Kennedy Shriver National Institute of Child Health and Human Development

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.7b00131

Reference28 articles.

1. Epothilons A and B: Antifungal and Cytotoxic Compounds from Sorangium cellulosum (Myxobacteria). Production, Physico-chemical and Biological Properties.

2. Epothilone A and B—Novel 16-Membered Macrolides with Cytotoxic Activity: Isolation, Crystal Structure, and Conformation in Solution

3. Preclinical discovery of ixabepilone, a highly active antineoplastic agent

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