Late-Stage Microsomal Oxidation Reduces Drug–Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189-Reference-Cited by-同舟云学术

Late-Stage Microsomal Oxidation Reduces Drug–Drug Interaction and Identifies Phosphodiesterase 2A Inhibitor PF-06815189

Published:2018-01-30 Issue:2 Volume:9 Page:68-72
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Stepan Antonia F.¹^ORCID,Tran Tuan P.²^ORCID,Helal Christopher J.²^ORCID,Brown Maria S.²,Chang Cheng²,O’Connor Rebecca E.²,De Vivo Michael¹,Doran Shawn D.²,Fisher Ethan L.²,Jenkinson Stephen³,Karanian David²,Kormos Bethany L.¹,Sharma Raman²,Walker Gregory S.²,Wright Ann S.²,Yang Edward X.²,Brodney Michael A.¹,Wager Travis T.¹^ORCID,Verhoest Patrick R.¹,Obach R. Scott²

Affiliation:

1. Pfizer Worldwide Research and Development, 610 Main Street, Cambridge, Massachusetts 02139, United States

2. Pfizer Worldwide Research and Development, Eastern Point Road, Groton, Connecticut 06340, United States

3. Pfizer Worldwide Research and Development, 10770 Science Center Drive, La Jolla, California 92121, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.7b00343

Reference28 articles.

1. Beck, E. M.; Stepan, A. F.; Webb, D.C–H Activation Approaches to Molecules;Royal Society of Chemistry, 2016; pp274–383.

2. The medicinal chemist's toolbox for late stage functionalization of drug-like molecules

3. Can the pharmaceutical industry reduce attrition rates?

4. Divergent C–H Functionalizations Directed by Sulfonamide Pharmacophores: Late-Stage Diversification as a Tool for Drug Discovery

5. Late-stage C–H functionalization of complex alkaloids and drug molecules via intermolecular rhodium-carbenoid insertion

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