Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor-Reference-Cited by-同舟云学术

Improving Metabolic Stability with Deuterium: The Discovery of BMT-052, a Pan-genotypic HCV NS5B Polymerase Inhibitor

Published:2017-07-03 Issue:7 Volume:8 Page:771-774
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Parcella Kyle¹^ORCID,Eastman Kyle¹,Yeung Kap-Sun¹^ORCID,Grant-Young Katharine A.¹,Zhu Juliang¹,Wang Tao¹,Zhang Zhongxing¹,Yin Zhiwei¹,Parker Dawn¹,Mosure Kathy¹,Fang Hua¹,Wang Ying-Kai¹,Lemm Julie¹,Zhuo Xiaoliang¹,Hanumegowda Umesh¹,Liu Mengping¹,Rigat Karen¹,Donoso Maria¹,Tuttle Maria¹,Zvyaga Tatyana¹,Haarhoff Zuzana¹,Meanwell Nicholas A.¹,Soars Matthew G.¹,Roberts Susan B.¹,Kadow John F.¹

Affiliation:

1. Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.7b00211

Reference15 articles.

1. World Health Organization Hepatitis C fact sheet. UpdatedJuly (2016.http://www.who.int/mediacentre/factsheets/fs164/en/(accessed 4/19/17).

2. Global Burden of Hepatitis C: Considerations for Healthcare Providers in the United States

3. Hepatitis C virus genotypes and quasispecies

4. Determining hepatitis C genotype by analyzing the sequence of the NS5b region

5. Hepatitis C Virus Genotype 7, a New Genotype Originating from Central Africa

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