Synthesis and Pharmacological Evaluation of Selective Histone Deacetylase 6 Inhibitors in Melanoma Models

Author:

Tavares Maurício T.1ORCID,Shen Sida1,Knox Tessa2,Hadley Melissa2,Kutil Zsófia3,Bařinka Cyril3,Villagra Alejandro2,Kozikowski Alan P.4ORCID

Affiliation:

1. Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago, Chicago, Illinois 60612, United States

2. Department of Biochemistry and Molecular Medicine, The George Washington University, Washington, DC 20052, United States

3. Institute of Biotechnology, BIOCEV, Prumyslova 595, 252 50 Vestec, Czech Republic

4. StarWise Therapeutics LLC, University Research Park, Inc., 510 Charmany Drive, Madison, Wisconsin 53719, United States

Funder

National Cancer Institute

National Institute of Neurological Disorders and Stroke

Melanoma Research Foundation

European Regional Development Fund

Grantov? Agentura Cesk? Republiky

Akademie Ved Cesk? Republiky

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Reference34 articles.

1. Global perspectives of contemporary epidemiological trends of cutaneous malignant melanoma

2. https://www.cancer.gov/about-cancer/treatment/drugs/fda-dabrafenib(accessed July 2017) andhttps://www.cancer.gov/about-cancer/treatment/drugs/fda-trametinib(accessed July 2017) .

3. Immune Checkpoint Blockade in Cancer Therapy

4. Acquired resistance to anti-PD1 therapy: checkmate to checkpoint blockade?

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