Synthesis and Evaluation of a 18F-Labeled Triazinediamine Analogue for Imaging Mutant IDH1 Expression in Gliomas by PET
Author:
Affiliation:
1. Department of Radiology and ‡Department of Pathology, Duke University Medical Center, Durham, North Carolina 27710, United States
Funder
National Cancer Institute
Duke University
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.7b00478
Reference23 articles.
1. Isocitrate Dehydrogenase 1 and 2 Mutations in Cancer: Alterations at a Crossroads of Cellular Metabolism
2. IDH1andIDH2Mutations in Gliomas
3. Cancer-associated IDH1 mutations produce 2-hydroxyglutarate
4. Oncometabolite 2-Hydroxyglutarate Is a Competitive Inhibitor of α-Ketoglutarate-Dependent Dioxygenases
5. IDH1 mutation is sufficient to establish the glioma hypermethylator phenotype
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