Discovery of VU6005649, a CNS Penetrant mGlu7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5-a]pyrimidines-Reference-Cited by-同舟云学术

Discovery of VU6005649, a CNS Penetrant mGlu7/8 Receptor PAM Derived from a Series of Pyrazolo[1,5-a]pyrimidines

Published:2017-09-12 Issue:10 Volume:8 Page:1110-1115
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Abe Masahito¹²,Seto Mabel¹²,Gogliotti Rocco G.¹²,Loch Matthew T.¹²,Bollinger Katrina A.²,Chang Sichen²,Engelberg Eileen M.¹²,Luscombe Vincent B.¹²,Harp Joel M.³,Bubser Michael¹²,Engers Darren W.¹²,Jones Carrie K.¹²⁴,Rodriguez Alice L.¹²,Blobaum Anna L.¹²,Conn P. Jeffrey¹²⁴,Niswender Colleen M.¹²⁴,Lindsley Craig W.¹²⁴^ORCID

Affiliation:

1. Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States

2. Vanderbilt Center for Neuroscience Drug Discovery, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States

3. Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, United States

4. Vanderbilt Kennedy Center, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States

Funder

William K. Warren Foundation

National Institute of Mental Health

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.7b00317

Reference31 articles.

1. Metabotropic Glutamate Receptors: Physiology, Pharmacology, and Disease

2. Practical Strategies and Concepts in GPCR Allosteric Modulator Discovery: Recent Advances with Metabotropic Glutamate Receptors

3. Increased Seizure Susceptibility in Mice Lacking Metabotropic Glutamate Receptor 7

4. Deficits in acquisition and extinction of conditioned responses in mGluR7 knockout mice

5. Activation of the mGlu7 receptor elicits antidepressant-like effects in mice

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4. Structural basis of allosteric modulation of metabotropic glutamate receptor activation and desensitization;2023-08-15

5. dx.doi.org/10.1124/molpharm.123.000678Pharmacol104:17-27, July 2023;MOL PHARMACOL;2023