Tuning the Cavity of Cyclodextrins: Altered Sugar Adaptors in Protein Pores-Reference-Cited by-同舟云学术

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Tuning the Cavity of Cyclodextrins: Altered Sugar Adaptors in Protein Pores

Published:2011-01-18 Issue:6 Volume:133 Page:1987-2001
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Li Wen-Wu¹,Claridge Timothy D. W.¹,Li Qiuhong¹,Wormald Mark R.²,Davis Benjamin G.¹,Bayley Hagan¹

Affiliation:

1. Department of Chemistry, University of Oxford, Chemical Research Laboratory, Mansfield Road, Oxford OX1 3TA, United Kingdom

2. Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja1100867

Reference74 articles.

1. Introduction and General Overview of Cyclodextrin Chemistry

2. Complexation Thermodynamics of Cyclodextrins

3. Cyclodextrins and Their Complexes

4. Cyclodextrin-based pharmaceutics: past, present and future

5. A Novel Concept of Reversing Neuromuscular Block: Chemical Encapsulation of Rocuronium Bromide by a Cyclodextrin-Based Synthetic Host The discovery of Org 25969 is the result of teamwork with contributions from a number of scientists both inside Organon and outside the company. We would like in particular to acknowledge the following scientists for their invaluable contributions: E. Hutchinson, D. Stevenson, R. Roy, and J. Pick for scaling-up the synthesis; F. Hope, S. Miller, and R. Mason for various in vitro and in vivo pharmacological testing; R. Watson, B. Montgomery, P. Desmond, and A. Osprey for all their analytical effort; and R. McGuire and J. Mestres for graphical presentation of the X-ray crystal structure of the Org 25969–rocuronium complex (Figure 3). We would also like to thank Prof. A. Cooper of Glasgow University who has critically reproduced our calorimetry data of Org 25969–rocuronium complexation (Figure 2).

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