Structure-Based Selectivity Optimization of Piperidine–Pteridine Derivatives as Potent Leishmania Pteridine Reductase Inhibitors-Reference-Cited by-同舟云学术

Structure-Based Selectivity Optimization of Piperidine–Pteridine Derivatives as Potent Leishmania Pteridine Reductase Inhibitors

Published:2012-09-19 Issue:19 Volume:55 Page:8318-8329
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Corona Paola¹,Gibellini Federica²,Cavalli Andrea³⁴,Saxena Puneet²,Carta Antonio¹,Loriga Mario¹,Luciani Rosaria²,Paglietti Giuseppe¹,Guerrieri Davide²,Nerini Erika²,Gupta Shreedhara⁵,Hannaert Véronique⁵,Michels Paul A. M.⁵,Ferrari Stefania²,Costi Paola M.²

Affiliation:

1. Dipartimento di Chimica e Farmacia, Università degli Studi di Sassari, via Muroni 23/a, 07100 Sassari, Italy

2. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Modena e Reggio Emilia, Via Campi 183, 41100 Modena, Italy

3. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Bologna, Via Belmeloro, 40126 Bologna, Italy

4. Drug Discovery and Development, Istituto Italiano di Tecnologia, via Morego 30, 16163 Genova, Italy

5. Research Unit for Tropical Diseases, de Duve Institute and Laboratory of Biochemistry, Université catholique de Louvain, Avenue Hippocrate 74, Postal Box B1.74.01, B-1200 Brussels, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm300563f

Reference19 articles.

1. Leishmaniasis emergence in Europe

2. One Health: The global challenge of epidemic and endemic leishmaniasis

3. Pteridine salvage throughout the Leishmania infectious cycle: implications for antifolate chemotherapy

4. Structures of dihydrofolate reductase-thymidylate synthase ofTrypanosoma cruziin the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate

5. Structure of and kinetic channelling in bifunctional dihydrofolate reductase–thymidylate synthase

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