Quantitative Measurement of Plasma 3-Hydroxyisovaleryl Carnitine by LC-MS/MS as a Novel Biomarker of Biotin Status in Humans

Author:

Horvath Thomas D.1,Stratton Shawna L.1,Bogusiewicz Anna1,Pack Lindsay1,Moran Jeffery1,Mock Donald M.1

Affiliation:

1. Departments of Biochemistry and Molecular Biology and Pharmacology and Toxicology, University of Arkansas for Medical Sciences, 4301 W. Markham Street, Little Rock, Arkansas 72205, and Public Health Laboratory, Arkansas Department of Health, 201 South Monroe Street, Little Rock, Arkansas 72205

Publisher

American Chemical Society (ACS)

Subject

Analytical Chemistry

Reference23 articles.

1. Marginal Biotin Deficiency Is Teratogenic

2. Teratogenic effects of maternal biotin deficiency on mouse embryos examined at midgestation

3. Mock, D.InModern Nutrition in Health and Disease,10thed.Shils, M. E., Shike, M., Ross, A. C., Caballero, B., and Cousins, R. J., Eds.Lippincott, Williams & Wilkins:Baltimore, MD, 2006; pp498−506.

4. Biotin Deficiency Per Se Is Teratogenic in Mice

5. Marginal Maternal Biotin Deficiency in CD-1 Mice Reduces Fetal Mass of Biotin-dependent Carboxylases

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