A 3D Similarity Method for Scaffold Hopping from Known Drugs or Natural Ligands to New Chemotypes
Author:
Affiliation:
1. Lead Discovery Center, Novartis Institutes for BioMedical Research Inc., 250 Massachusetts Ave., Cambridge, Massachusetts 02139
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm049654z
Reference73 articles.
1. “Scaffold-Hopping” by Topological Pharmacophore Search: A Contribution to Virtual Screening
2. Toward General Methods of Targeted Library Design: Topomer Shape Similarity Searching with Diverse Structures as Queries
3. dbtop: Topomer similarity searching of conventional structure databases
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