Neural Networks as Valuable Tools To Differentiate between Sesquiterpene Lactones’ Inhibitory Activity on Serotonin Release and on NF-κB-Reference-Cited by-同舟云学术

Neural Networks as Valuable Tools To Differentiate between Sesquiterpene Lactones’ Inhibitory Activity on Serotonin Release and on NF-κB

Published:2008-02-14 Issue:5 Volume:51 Page:1324-1332
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wagner Steffen¹,Arce Raul¹,Murillo Renato¹,Terfloth Lothar¹,Gasteiger Johann¹,Merfort Irmgard¹

Affiliation:

1. Institut für Pharmazeutische Wissenschaften, Lehrstuhl für Pharmazeutische Biologie and Biotechnologie, Universität Freiburg, 79104 Freiburg, Germany, Escuela de Quimica y Centro de Investigación en Productos Naturales (CIPRONA), Universidad de Costa Rica, San José, Costa Rica, and Molecular Networks GmbH−Computerchemie, 91052 Erlangen, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm701318x

Reference41 articles.

1. Anti-Cancer Potential of Sesquiterpene Lactones: Bioactivity and Molecular Mechanisms

2. Cysteine 38 in p65/NF-κB Plays a Crucial Role in DNA Binding Inhibition by Sesquiterpene Lactones

3. Sesquiterpene Lactones Specifically Inhibit Activation of NF-κB by Preventing the Degradation of IκB-α and IκB-β

4. The Anti-inflammatory Sesquiterpene Lactone Helenalin Inhibits the Transcription Factor NF-κB by Directly Targeting p65

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