Synthesis and In Vitro Antiplatelet Activity of New 4-(1-Piperazinyl)coumarin Derivatives. Human Platelet Phosphodiesterase 3 Inhibitory Properties of the Two Most Effective Compounds Described and Molecular Modeling Study on Their Interactions with Phosphodiesterase 3A Catalytic Site-Reference-Cited by-同舟云学术

Synthesis and In Vitro Antiplatelet Activity of New 4-(1-Piperazinyl)coumarin Derivatives. Human Platelet Phosphodiesterase 3 Inhibitory Properties of the Two Most Effective Compounds Described and Molecular Modeling Study on Their Interactions with Phosphodiesterase 3A Catalytic Site

Published:2007-05-15 Issue:12 Volume:50 Page:2886-2895
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Roma Giorgio¹,Di Braccio Mario¹,Grossi Giancarlo¹,Piras Daniela¹,Leoncini Giuliana¹,Bruzzese Debora¹,Signorello Maria Grazia¹,Fossa Paola¹,Mosti Luisa¹

Affiliation:

1. Dipartimento di Scienze Farmaceutiche, Università di Genova, Viale Benedetto XV n. 3, I-16132 Genoa, Italy, and Dipartimento di Medicina Sperimentale, Sezione Biochimica, Università di Genova, Viale Benedetto XV n. 1, I-16132 Genoa, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0611511

Reference23 articles.

1. Cyclic nucleotide phosphodiesterases: functional implications of multiple isoforms

2. Synthesis and anti-platelet activity of some 2-(dialkylamino)chromones

3. Synthesis and antiplatelet activity of 2-(diethylamino)-7-ethoxychromone and related compounds

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