Reversible Carboxamide-Mediated Internal Activation at C(6) of 2-Chloro-4-anilino-1H-pyrrolo[2,3-d]pyrimidines

Author:

Chamberlain Stanley D.1,Gerding Roseanne M.1,Lei Huangshu1,Moorthy Ganesh1,Patnaik Samarjit1,Redman Anikó M.1,Stevens Kirk L.1,Wilson Joseph W.1,Yang Bin1,Shotwell J. Brad1

Affiliation:

1. GlaxoSmithKline, Oncology R&D, 5 Moore Drive, Research Triangle Park, North Carolina 27709

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Reference16 articles.

1. Burdick, D.; Liang, J.Pyrimidine Kinase Inhibitors. WO 2007/120339 A1, December 15,2006.

2. Inhibition of both focal adhesion kinase and insulin-like growth factor-I receptor kinase suppresses glioma proliferation in vitro and in vivo

3. Identification of NVP-TAE684, a potent, selective, and efficacious inhibitor of NPM-ALK

4. cImbach, P.; Kawahar, E.; Konishi, K.; Matsuura, N.; Miyake, T.; Ohmori, O.; Roesel, J.; Teno, N.; Umemura, I.Pyrimidine Derivatives. WO 2006/021454 A2, August 27,2004.

5. dGarcia-Echeverria, C.; Kanazawa, T.; Kawahara, E.; Masuya, K.; Matsuura, N.; Miyake, T.; Ohmori, O.; Umemura, I.; Steensma, R.; Chopiuk, G.; Jiang, J.; Wan, Y.; Ding, Q.; Zhang, Q.; Gray, N.; Karanewsky, D.2,4-Pyrimidinediamines Useful in the Treatment of Neoplastic Diseases, Inflammatory and Immune System Disorders. WO 2005/016894 A1, September 24,2003.

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