Clarification of the Binding Mode of Teleocidin and Benzolactams to the Cys2 Domain of Protein Kinase Cδ by Synthesis of Hydrophobically Modified, Teleocidin-Mimicking Benzolactams and Computational Docking Simulation-Reference-Cited by-同舟云学术

Clarification of the Binding Mode of Teleocidin and Benzolactams to the Cys2 Domain of Protein Kinase Cδ by Synthesis of Hydrophobically Modified, Teleocidin-Mimicking Benzolactams and Computational Docking Simulation

Published:1998-04-01 Issue:9 Volume:41 Page:1476-1496
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Endo Yasuyuki¹,Takehana Shunji¹,Ohno Michihiro¹,Driedger Paul E.¹,Stabel Silvia¹,Mizutani Miho Y.¹,Tomioka Nobuo¹,Itai Akiko¹,Shudo Koichi¹

Affiliation:

1. Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113, Japan, Procyon Pharmaceuticals, Inc., 165 New Boston Street, Woburn, Massachusetts 01801, Max-Delbück Laboratorium, Carl-von-Linné-Weg 10, D-5000 Köln 30, Germany, and Institute of Medicinal Molecular Design, 5-24-5, Hongo, Bunkyo-ku, Tokyo 113, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm970704s

Reference53 articles.

1. A possible naturally occurring tumor promoter, teleocidin B from Streptomyces

2. Indole alkaloids: dihydroteleocidin B, teleocidin, and lyngbyatoxin A as members of a new class of tumor promoters.

3. Molecular requirements for epigenetic modulators. Synthesis of active fragments of teleocidins and lyngbyatoxin.

4. Synthesis of optically active teleocidin derivatives. Absolute configuration of teleocidin B and olivoretin A.

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