Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors-Reference-Cited by-同舟云学术

Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Stereopure Lactam-Based HIV-1 Protease Inhibitors

Published:2012-03-13 Issue:6 Volume:55 Page:2724-2736
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wu Xiongyu¹,Öhrngren Per¹,Joshi Advait A.¹,Trejos Alejandro¹,Persson Magnus²,Arvela Riina K.¹,Wallberg Hans³,Vrang Lotta³,Rosenquist Åsa³,Samuelsson Bertil B.³,Unge Johan⁴,Larhed Mats¹

Affiliation:

1. Department of Medicinal Chemistry, Organic Pharmaceutical Chemistry, BMC, Uppsala University, P.O. Box 574, SE-751 23 Uppsala, Sweden

2. Department of Cell and Molecular Biology, Structural Biology, BMC, Uppsala University, P.O. Box 596, SE-751 24 Uppsala, Sweden

3. Medivir AB, P.O. Box 1086, SE-141 22 Huddinge, Sweden

4. MAX IV-Laboratory, Lund University, P.O. Box 118, SE-221 00 Lund, Sweden

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm201620t

Reference70 articles.

1. Isolation of a T-Lymphotropic Retrovirus from a Patient at Risk for Acquired Immune Deficiency Syndrome (AIDS)

2. Isolation of Human T-Cell Leukemia Virus in Acquired Immune Deficiency Syndrome (AIDS)

3. Rational Design of Peptide-Based HIV Proteinase Inhibitors

4. A Controlled Trial of Two Nucleoside Analogues plus Indinavir in Persons with Human Immunodeficiency Virus Infection and CD4 Cell Counts of 200 per Cubic Millimeter or Less

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