Hepatitis C Virus NS5A Replication Complex Inhibitors. Part 6: Discovery of a Novel and Highly Potent Biarylimidazole Chemotype with Inhibitory Activity Toward Genotypes 1a and 1b Replicons-Reference-Cited by-同舟云学术

Hepatitis C Virus NS5A Replication Complex Inhibitors. Part 6: Discovery of a Novel and Highly Potent Biarylimidazole Chemotype with Inhibitory Activity Toward Genotypes 1a and 1b Replicons

Published:2014-01-17 Issue:5 Volume:57 Page:1995-2012
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Belema Makonen¹,Nguyen Van N.¹,Romine Jeffrey L.¹,St. Laurent Denis R.¹,Lopez Omar D.¹,Goodrich Jason T.¹,Nower Peter T.¹,O’Boyle Donald R.¹,Lemm Julie A.¹,Fridell Robert A.¹,Gao Min¹,Fang Hua¹,Krause Rudolph G.¹,Wang Ying-Kai¹,Oliver A. Jayne¹,Good Andrew C.¹,Knipe Jay O.¹,Meanwell Nicholas A.¹,Snyder Lawrence B.¹

Affiliation:

1. Departments of Discovery Chemistry, ‡Virology, §Lead Discovery and Optimization, ∥Computer-Assisted Drug Design, and ⊥Metabolism and Pharmacokinetics, Bristol-Myers Squibb Research and Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm4016203

Reference25 articles.

1. Understanding the hepatitis C virus life cycle paves the way for highly effective therapies

2. Novel therapies for hepatitis C — one pill fits all?

3. Review of direct-acting antiviral agents for the treatment of chronic hepatitis C

4. Current and Future Therapies for Hepatitis C Virus Infection

5. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect

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