1. Department of Pharmacology and Toxicology, Center for Human Toxicology, University of Utah, Salt Lake City, Utah 84112, Drug Disposition, Lilly Research Laboratories, Lilly Corporate Center, Indianapolis, Indiana, 46285, Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research and Development, 2800 Plymouth Road, Ann Arbor, Michigan 48105, and Metabolism and Pharmacokinetics, Bristol Myers Squibb, Route 141, Wilmington, Delaware 19880