Enantioselective, Biocatalytic Reduction of 3-Substituted Cyclopentenones: Application to the Asymmetric Synthesis of an hNK-1 Receptor Antagonist-Reference-Cited by-同舟云学术

Enantioselective, Biocatalytic Reduction of 3-Substituted Cyclopentenones: Application to the Asymmetric Synthesis of an hNK-1 Receptor Antagonist

Published:2011-02-08 Issue:5 Volume:13 Page:1004-1007
ISSN:1523-7060
Container-title:Organic Letters
language:en
Short-container-title:Org. Lett.

Author:

Campos Kevin R.¹,Klapars Artis¹,Kohmura Yoshinori¹,Pollard David¹,Ishibashi Hideaki¹,Kato Shinji¹,Takezawa Akihiro¹,Waldman Jacob H.¹,Wallace Debra J.¹,Chen Cheng-yi¹,Yasuda Nobuyoshi¹

Affiliation:

1. Department of Process Chemistry, Merck Research Laboratories, P.O. Box 2000, Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/ol1030348

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4. The novel NK1 receptor antagonist MK–0869 (L–754,030) and its water soluble phosphoryl prodrug, L–758,298, inhibit acute and delayed cisplatin-induced emesis in ferrets

5. In vitro and in vivo predictors of the anti-emetic activity of tachykinin NK1 receptor antagonists

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