Synthesis of (E)-8-(3-Chlorostyryl)caffeine Analogues Leading to 9-Deazaxanthine Derivatives as Dual A2A Antagonists/MAO-B Inhibitors-Reference-Cited by-同舟云学术

Synthesis of (E)-8-(3-Chlorostyryl)caffeine Analogues Leading to 9-Deazaxanthine Derivatives as Dual A2A Antagonists/MAO-B Inhibitors

Published:2013-01-16 Issue:3 Volume:56 Page:1247-1261
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rivara Silvia¹,Piersanti Giovanni²,Bartoccini Francesca²,Diamantini Giuseppe²,Pala Daniele¹,Riccioni Teresa³,Stasi Maria Antonietta³,Cabri Walter³,Borsini Franco³,Mor Marco¹,Tarzia Giorgio²,Minetti Patrizia³

Affiliation:

1. Dipartimento di Farmacia, Università degli Studi di Parma, Viale G.P. Usberti 27 A, I-43124 Parma, Italy

2. Department of Biomolecular Sciences, University of Urbino, Piazza Rinascimento 6, I-61029 Urbino (PU), Italy

3. Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Via Pontina Km 30,400, I-00040 Pomezia, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301686s

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1. Hybrid-Based Multi-Target Ligands for the Treatment of Alzheimer's Disease

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5. Adenosine A2A antagonists with potent anti-cataleptic activity

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