Synthesis of (E)-8-(3-Chlorostyryl)caffeine Analogues Leading to 9-Deazaxanthine Derivatives as Dual A2A Antagonists/MAO-B Inhibitors-Reference-Cited by-同舟云学术

Synthesis of (E)-8-(3-Chlorostyryl)caffeine Analogues Leading to 9-Deazaxanthine Derivatives as Dual A2A Antagonists/MAO-B Inhibitors

Published:2013-01-16 Issue:3 Volume:56 Page:1247-1261
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Rivara Silvia¹,Piersanti Giovanni²,Bartoccini Francesca²,Diamantini Giuseppe²,Pala Daniele¹,Riccioni Teresa³,Stasi Maria Antonietta³,Cabri Walter³,Borsini Franco³,Mor Marco¹,Tarzia Giorgio²,Minetti Patrizia³

Affiliation:

1. Dipartimento di Farmacia, Università degli Studi di Parma, Viale G.P. Usberti 27 A, I-43124 Parma, Italy

2. Department of Biomolecular Sciences, University of Urbino, Piazza Rinascimento 6, I-61029 Urbino (PU), Italy

3. Sigma-Tau Industrie Farmaceutiche Riunite S.p.A., Via Pontina Km 30,400, I-00040 Pomezia, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301686s

Reference88 articles.

1. Hybrid-Based Multi-Target Ligands for the Treatment of Alzheimer's Disease

2. Multimodal drugs and their future for Alzheimer's and Parkinson's disease

3. The emergence of designed multiple ligands for neurodegenerative disorders

4. Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists

5. Adenosine A2A antagonists with potent anti-cataleptic activity

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