New Approach to the Practical Synthesis of Tri- or Tetrasubstituted Pyrimidine Derivatives: A Four-Component Coupling Reaction from a Functionalized Silane, Two Types of Aromatic Nitriles, and Acetals
Author:
Affiliation:
1. Department of Pure and Applied Chemistry, Faculty of Science and Technology, Tokyo University of Science (RIKADAI), Noda, Chiba 278-8510, Japan
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ol051901l
Reference20 articles.
1. (a) Joule, J. A.; Mills, K.Heterocyclic Chemistry, 4th ed.; Blackwell Science Ltd. Cambridge, MA, 2000; pp 194−232.
2. The chemistry of .beta.-enaminonitriles as versatile reagents in heterocyclic synthesis
3. Pyrimido [4,5-d]pyrimidines. Part I
4. Synthese von Pyrimidinen aus Malondiimidsäureestern
5. A facile one step synthesis of novel ethyl 2,6-bis(trifluoromethyl)-4-hydroxypyrimidine-5-carboxylate
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