Synthesis and Evaluation of Azetidinone Analogues of Combretastatin A-4 as Tubulin Targeting Agents-Reference-Cited by-同舟云学术

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Synthesis and Evaluation of Azetidinone Analogues of Combretastatin A-4 as Tubulin Targeting Agents

Published:2010-11-16 Issue:24 Volume:53 Page:8569-8584
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

O’Boyle Niamh M.¹,Carr Miriam¹,Greene Lisa M.²,Bergin Orla³,Nathwani Seema M.²,McCabe Thomas⁴,Lloyd David G.⁵,Zisterer Daniela M²,Meegan Mary J.¹

Affiliation:

1. School of Pharmacy and Pharmaceutical Sciences, Centre for Synthesis and Chemical Biology, Trinity College Dublin, Dublin 2, Ireland

2. School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland

3. UCD Conway Institute and School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Dublin 4, Ireland

4. School of Chemistry, Trinity College Dublin, Dublin 2, Ireland

5. Molecular Design Group, School of Biochemistry and Immunology, Trinity College Dublin, Dublin 2, Ireland

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101115u

Reference74 articles.

1. Tubulin and microtubule structure

2. Miniaturized Formats for Efficient Mass Spectrometry-Based Proteomics and Therapeutic Development

3. Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin

4. Mechanism of colchicine-dimer addition to microtubule ends: implications for the microtubule polymerization mechanism

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2. Design, synthesis, and evaluation of anti-breast cancer activity of colchicine - combretastatin A-4 analogues containing quinoline as microtubule-targeting agents;Journal of Molecular Structure;2024-09

3. Inhibition of β-lactamase by Novel Benzothiazole-Coupled Azetidinone Derivatives: A Comprehensive Study Using an In silico and In vitro Approaches Against Multi Drug Resistant Bacteria;Journal of Computational Biophysics and Chemistry;2024-08-08

4. Novel (±)-trans-β-lactam ureas: Synthesis, in silico and in vitro biological profiling;Acta Pharmaceutica;2024-03-01

5. N-Benzyl arylamide derivatives as novel and potent tubulin polymerization inhibitors against gastric cancers: Design, structure–activity relationships and biological evaluations;Chinese Chemical Letters;2024-02

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