Structural Insights into a Unique Inhibitor Binding Pocket in Kinesin Spindle Protein-Reference-Cited by-同舟云学术

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Structural Insights into a Unique Inhibitor Binding Pocket in Kinesin Spindle Protein

Published:2013-02-04 Issue:6 Volume:135 Page:2263-2272
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Ulaganathan Venkatasubramanian¹,Talapatra Sandeep K.¹,Rath Oliver¹,Pannifer Andrew²,Hackney David D.³,Kozielski Frank¹

Affiliation:

1. The Molecular Motors Laboratory, The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, Scotland, U.K.

2. Drug Discovery Programme, The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Glasgow G61 1BD, Scotland, U.K.

3. Department of Biological Sciences, Carnegie Mellon University, 4400 Fifth Avenue, Pittsburgh, Pennsylvania 15213, United States

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja310377d

Reference23 articles.

1. Southwest Oncology Group Phase II Study of Ispinesib in Androgen-Independent Prostate Cancer Previously Treated with Taxanes

2. A phase I study of ispinesib, a kinesin spindle protein inhibitor, administered weekly for three consecutive weeks of a 28-day cycle in patients with solid tumors

3. Antitumor activity of an allosteric inhibitor of centromere-associated protein-E

4. A phase I trial of ispinesib, a kinesin spindle protein inhibitor, with docetaxel in patients with advanced solid tumours

5. Inhibition of a Mitotic Motor Protein: Where, How, and Conformational Consequences

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