1. Graduate School of Life Science and Frontier Research Center for Post-Genome Science and Technology, Hokkaido University, N21, W11, Kita-ku, Sapporo 001-0021, Japan
2. Shionogi Drug Discovery Innovation Center, Hokkaido University, N21, W11, Kita-ku, Sapporo 001-0021, Japan
3. Shionogi & Co. Ltd., Chuo-ku, Osaka 541-0045, Japan