6-Methoxy-7-benzofuranoxy and 6-Methoxy-7-indolyloxy Analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 Discovery of a Potent and Selective α1D-Adrenoceptor Antagonist-Reference-Cited by-同舟云学术

6-Methoxy-7-benzofuranoxy and 6-Methoxy-7-indolyloxy Analogues of 2-[2-(2,6-Dimethoxyphenoxy)ethyl]aminomethyl-1,4-benzodioxane (WB4101):1 Discovery of a Potent and Selective α1D-Adrenoceptor Antagonist

Published:2013-07-31 Issue:16 Volume:56 Page:6402-6412
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Fumagalli Laura¹,Pallavicini Marco¹,Budriesi Roberta²,Bolchi Cristiano¹,Canovi Mara³,Chiarini Alberto²,Chiodini Giuseppe¹,Gobbi Marco³,Laurino Paola⁴,Micucci Matteo²,Straniero Valentina¹,Valoti Ermanno¹

Affiliation:

1. Dipartimento di Scienze Farmaceutiche, Università degli Studi di Milano, via Mangiagalli 25, I-20133, Milano, Italy

2. Dipartimento di Scienze Farmaceutiche, Università di Bologna, via Belmeloro 6, I-40126 Bologna, Italy

3. IRCCS - Istituto di Ricerche Farmacologiche ‘Mario Negri’, via La Masa 19, I-20156 Milano, Italy

4. Department of Biological Chemistry, Weizman Institute of Science, IL-76100, Rehovot, Israel

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm400867d

Reference28 articles.

1. Synthesis and pharmacological properties of a series of 2-substituted aminomethyl-1,4-benzodioxanes

2. Subtypes of functional α1-adrenoceptor

3. BMY 7378 is a selective antagonist of the D subtype of α1-adrenoceptors

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