Octanol/Water Partition Coefficients of Sulfonamides: Experimental Determination and Calculation Using Physicochemical Descriptors

Author:

Raevsky Oleg A.1,Perlovich German L.1,Kazachenko Vladimir P.1,Strakhova Nadezda N.1,Schaper Klaus-J.1

Affiliation:

1. Department of Computer-Aided Molecular Design, Institute of Physiologically Active Compounds of Russian Academy of Sciences, 142432, Chernogolovka, Moscow region, Russia, Division of Structural Biochemistry, Research Center Borstel, Leibniz Center for Medicine and Biosciences, Parkallee 1-40, D-23845 Borstel, Germany, and Institute of Solution Chemistry, Russian Academy of Sciences, 153045 Ivanovo, Russia

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

Reference20 articles.

1. Mode of action and quantitative structure-activity relationship of sulfonamides in biological systems of different complexity (enzymes, bacteria, rat, and human)

2. Korolkovas, A.Essentials of Medicinal Chemistry,2nded.Wiley:New York, 1988; pp699−716.

3. Mandell, G. L.; Sande, M. A.; Antimicrobial agents.InGoodman and Gilman’s The Pharmacological Basis of Therapeutics,8thed.Gilman, A.; Rall, T. W.; Nies, A. S.; Taylor, P.,Eds.McGraw-Hill:Singapore, 1992; Vol.2, pp1047−1057.

4. Studying thermodynamic aspects of sublimation, solubility and solvation processes and crystal structure analysis of some sulfonamides

5. Sulfonamides as a subject to study molecular interactions in crystals and solutions: Sublimation, solubility, solvation, distribution and crystal structure

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