X-ray Snapshot of HIV-1 Protease in Action: Observation of Tetrahedral Intermediate and Short Ionic Hydrogen Bond SIHB with Catalytic Aspartate-Reference-Cited by-同舟云学术

X-ray Snapshot of HIV-1 Protease in Action: Observation of Tetrahedral Intermediate and Short Ionic Hydrogen Bond SIHB with Catalytic Aspartate

Published:2010-04-16 Issue:18 Volume:132 Page:6366-6373
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Das Amit¹,Mahale Smita¹,Prashar Vishal¹,Bihani Subhash¹,Ferrer J.-L.¹,Hosur M. V.¹

Affiliation:

1. Protein Crystallography Section, Solid State Physics Division, Bhabha Atomic Research Centre, Trombay, Mumbai-400085, India, National Institute for Research in Reproductive Health, Parel, Mumbai-400074, India, and LCCP/GSY, Institute de Biologie Structurale, J.-P. Ebel CEA-CNRS-UJF, 41, rue Jules Horowitz, F-38027 Grenoble Cedex 1, France

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja100002b

Reference57 articles.

1. Human immunodeficiency virus protease expressed in Escherichia coli exhibits autoprocessing and specific maturation of the gag precursor.

2. Active human immunodeficiency virus protease is required for viral infectivity.

3. Conformational aspects of inhibitor design: enzyme–substrate interactions in the transition state

4. INHIBITORS OF HIV-1 PROTEASE: A Major Success of Structure-Assisted Drug Design

5. Theoretical Proposal of a Catalytic Mechanism for the HIV-1 Protease Involving an Enzyme-Bound Tetrahedral Intermediate

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