1. Institute of Anatomy and Cell Biology, School of Medicine, National Yang-Ming University, No. 155, Section 2, Li-Non Street, Taipei 12212, Taiwan, School of Medicine, Fu-Jen Catholic University, Hsin-Chuang, Taipei County 24205, Taiwan, and Department of Internal Medicine, Kaohsiung Armed Forces General Hospital, No. 2, Chung Cheng First Road, Lingya District, Kaohsiun, 80284, Taiwan