Predicting and Improving the Membrane Permeability of Peptidic Small Molecules
Author:
Affiliation:
1. Department of Pharmaceutical Chemistry and ‡Small Molecule Discovery Center, University of California, San Francisco, California, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm201634q
Reference28 articles.
1. Intramolecular Hydrogen Bonding in Medicinal Chemistry
2. Conformational Flexibility, Internal Hydrogen Bonding, and Passive Membrane Permeability: Successful in Silico Prediction of the Relative Permeabilities of Cyclic Peptides
3. Testing the Conformational Hypothesis of Passive Membrane Permeability Using Synthetic Cyclic Peptide Diastereomers
4. Utilization of an Intramolecular Hydrogen Bond To Increase the CNS Penetration of an NK1 Receptor Antagonist
5. Intramolecular hydrogen bonding to improve membrane permeability and absorption in beyond rule of five chemical space
Cited by 99 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. Molecular Mechanism of P53 Peptide Permeation through Lipid Membranes from Solid-State NMR Spectroscopy and Molecular Dynamics Simulations;Journal of the American Chemical Society;2024-08-07
2. Cyclin A/B RxL Macrocyclic Inhibitors to Treat Cancers with High E2F Activity;2024-08-01
3. Predicting Peptide Permeability Across Diverse Barriers: A Systematic Investigation;Molecular Pharmaceutics;2024-07-20
4. Substitution-Induced Mechanistic Switching in SNAr-Warheads for Cysteine Proteases;Molecules;2024-06-04
5. DES-igning the future of drug delivery: A journey from fundamentals to drug delivery applications;Journal of Molecular Liquids;2024-04
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3