6-[2-(Phosphonomethoxy)alkoxy]pyrimidines with Antiviral Activity

Author:

Holý Antonín1,Votruba Ivan1,Masojídková Milena1,Andrei Graciela1,Snoeck Robert1,Naesens Lieve1,De Clercq Erik1,Balzarini Jan1

Affiliation:

1. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám. 2, CZ-166 10 Praha 6, Czech Republic, and Rega Institute for Medical Research, Katholieke Universiteit Leuven, Minderbroedersstraat 10, B-3000 Leuven, Belgium

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference72 articles.

1. Reviews:  (a) Holý, A. Phosphonylmethyl analogues of nucleotides and their derivatives:  chemistry and biology.Nucleosides Nucleotides1987,6,147−155. (b) Holý A. Isopolar Phosphorus-Modified Nucleotide Analogues. InAdvances in Antiviral Drug Design; De Clercq, E., Ed.; JAI Press:  Greenwich, CT, 1994; pp 179−232. (c) Freeman, S.; Gardiner, J.M. Acyclic nucleosides as antiviral compounds.Mol. Biotechnol.1996,5,125−137.

2. HPMPC (cidofovir), PMEA (adefovir) and Related Acyclic Nucleoside Phosphonate Analogues: A Review of their Pharmacology and Clinical Potential in the Treatment of Viral Infections

3. Synthesis and in vitro evaluation of a phosphonate prodrug: bis(pivaloyloxymethyl) 9-(2-phosphonylmethoxyethyl)adenine

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