Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity-Reference-Cited by-同舟云学术

Discovery of 4-{4-[(3R)-3-Methylmorpholin-4-yl]-6-[1-(methylsulfonyl)cyclopropyl]pyrimidin-2-yl}-1H-indole (AZ20): A Potent and Selective Inhibitor of ATR Protein Kinase with Monotherapy in Vivo Antitumor Activity

Published:2013-03-01 Issue:5 Volume:56 Page:2125-2138
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Foote Kevin M.¹,Blades Kevin¹,Cronin Anna¹,Fillery Shaun¹,Guichard Sylvie S.¹,Hassall Lorraine¹,Hickson Ian²,Jacq Xavier²,Jewsbury Philip J.¹,McGuire Thomas M.¹,Nissink J. Willem M.¹,Odedra Rajesh¹,Page Ken¹,Perkins Paula¹,Suleman Abid¹,Tam Kin¹,Thommes Pia¹,Broadhurst Rebecca¹,Wood Christine¹

Affiliation:

1. AstraZeneca, Mereside, Alderley Park, Macclesfield, Cheshire SK10 4TG, U.K.

2. KuDOS Pharmaceuticals, Cambridge Science Park, Milton Road, Cambridge, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm301859s

Reference43 articles.

1. ATR: an essential regulator of genome integrity

2. Toward Maintaining the Genome: DNA Damage and Replication Checkpoints