PASylation of Murine Leptin Leads to Extended Plasma Half-Life and Enhanced in Vivo Efficacy
Author:
Affiliation:
1. XL-protein GmbH, Lise-Meitner-Strasse 30, 85354 Freising, Germany
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Pharmaceutical Science,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/mp5007147
Reference74 articles.
1. Positional cloning of the mouse obese gene and its human homologue
2. Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
3. Leptin at 14 y of age: an ongoing story
4. Leptin enters the brain by a saturable system independent of insulin
5. Leptin activation of Stat3 in the hypothalamus of wild–type and ob/ob mice but not db/db mice
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