Detecting a Quasi-stable Imine Species on the Reaction Pathway of SHV-1 β-Lactamase and 6β-(Hydroxymethyl)penicillanic Acid Sulfone
Author:
Affiliation:
1. Research Service, Louis Stokes Cleveland Veterans Affairs Medical Center, Cleveland, Ohio 44106, United States
2. Department of Chemistry, Southern Methodist University, Dallas, Texas 75275, United States
Funder
National Institute of Allergy and Infectious Diseases
National Institute of General Medical Sciences
Cleveland Department of Veterans Affairs
Publisher
American Chemical Society (ACS)
Subject
Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/bi501197t
Reference34 articles.
1. An Enzyme from Bacteria able to Destroy Penicillin
2. The structure of β-lactamases
3. Three Decades of β-Lactamase Inhibitors
4. Different Intermediate Populations Formed by Tazobactam, Sulbactam, and Clavulanate Reacting with SHV-1 β-Lactamases: Raman Crystallographic Evidence
5. High Resolution Crystal Structures of the trans-Enamine Intermediates Formed by Sulbactam and Clavulanic Acid and E166A SHV-1 β-Lactamase
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