1. Department of Occupational and Environmental Health, Interdisciplinary Graduate Program in Human Toxicology, High Resolution Mass Spectrometry Facility, Central High-Field NMR Research Facility, Department of Chemistry, College of Pharmacy, and Seamans Center for the Engineering Art and Sciences, University of Iowa, Iowa City, Iowa 52242, and Institute of Life Sciences, Saxion University of Applied Sciences, 7500 AB, Enschede, The Netherlands