Application of the Phosphoramidate ProTide Approach to 4‘-Azidouridine Confers Sub-micromolar Potency versus Hepatitis C Virus on an Inactive Nucleoside-Reference-Cited by-同舟云学术

Application of the Phosphoramidate ProTide Approach to 4‘-Azidouridine Confers Sub-micromolar Potency versus Hepatitis C Virus on an Inactive Nucleoside

Published:2007-03-17 Issue:8 Volume:50 Page:1840-1849
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Perrone Plinio¹,Luoni Giovanna M.¹,Kelleher Mary Rose¹,Daverio Felice¹,Angell Annette¹,Mulready Sinead¹,Congiatu Costantino¹,Rajyaguru Sonal¹,Martin Joseph A.¹,Levêque Vincent¹,Le Pogam Sophie¹,Najera Isabel¹,Klumpp Klaus¹,Smith David B.¹,McGuigan Christopher¹

Affiliation:

1. Welsh School of Pharmacy, Cardiff University, King Edward VII Avenue, Cardiff CF10 3XF, UK, and Roche Palo Alto, 3431 Hillview Avenue, Palo Alto, California 94304

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0613370

Reference27 articles.

1. An Assay for Circulating Antibodies to a Major Etiologic Virus of Human Non-A, Non-B Hepatitis

2. Pathogenesis, diagnosis and management of hepatitis C

3. Challenges and successes in developing new therapies for hepatitis C

4. Recent development of therapeutics for chronic HCV infection

5. Sugar-Modified Nucleosides in Past 10 Years, A Review

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