Ligandless Heck Coupling between a Halogenated Aniline and Acrylonitrile Catalyzed by Pd/C: Development and Optimization of an Industrial-Scale Heck Process for the Production of a Pharmaceutical Intermediate-Reference-Cited by-同舟云学术

Ligandless Heck Coupling between a Halogenated Aniline and Acrylonitrile Catalyzed by Pd/C: Development and Optimization of an Industrial-Scale Heck Process for the Production of a Pharmaceutical Intermediate

Published:2008-05-01 Issue:3 Volume:12 Page:530-536
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Schils Didier¹,Stappers Fred¹,Solberghe Geoffrey¹,van Heck Richard¹,Coppens Michelle¹,Van den Heuvel Dirk¹,Van der Donck Peter¹,Callewaert Tom¹,Meeussen Frank¹,De Bie Erika¹,Eersels Kristof¹,Schouteden Ellen¹

Affiliation:

1. Johnson and Johnson Pharmaceutical Research and Development, a Division of Janssen Pharmaceutica, API Development, Turnhoutseweg 30, B-2340 Beerse, Belgium

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op8000383

Reference33 articles.

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3. c Review: Beletskaya, I. P. Cheprakov, A. V.Chem. Rev.2000, 100, 3009−3066 and references therein.

4. a Review: Littke, A. Fu, G.Angew. Chem., Int. Ed.2002, 41, 4176−4211.

5. b Review: Whitecombe, N. J. Hii, K. Gibson, S.Tetrahedron2001, 57, 7449−7476.

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