A Practical Use of Ligand Efficiency Indices Out of the Fragment-Based Approach: Ligand Efficiency-Guided Lead Identification of Soluble Epoxide Hydrolase Inhibitors-Reference-Cited by-同舟云学术

A Practical Use of Ligand Efficiency Indices Out of the Fragment-Based Approach: Ligand Efficiency-Guided Lead Identification of Soluble Epoxide Hydrolase Inhibitors

Published:2010-12-30 Issue:3 Volume:54 Page:851-857
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Tanaka Daisuke¹,Tsuda Yusuke¹,Shiyama Takaaki¹,Nishimura Tamiki¹,Chiyo Naoki²,Tominaga Yukio²,Sawada Nobuyuki¹,Mimoto Tsutomu¹,Kusunose Naoto¹

Affiliation:

1. Chemistry Research Laboratories

2. Genomic Science Laboratories

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101273e

Reference27 articles.

1. Functional group contributions to drug-receptor interactions

2. The maximal affinity of ligands

3. Ligand efficiency: a useful metric for lead selection

4. Ligand efficiency indices as guideposts for drug discovery

5. Fragment‐based Approaches in Drug Discovery

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