1. Department of Chemistry, University of Virginia, Charlottesville, Virginia 22904, Department of Biochemistry and Molecular Genetics, University of Virginia, Charlottesville, Virginia 22908, Laboratory of Chromatin Biology, The Rockefeller University, New York, New York 10021, Department of Pharmacology and Toxicology, Virginia Commonwealth University, Richmond, Virginia 23298, and Department of Pathology, University of Virginia, Charlottesville, Virginia 22904