Tetrahedral Intermediates in Thiamin Diphosphate-Dependent Decarboxylations Exist as a 1‘,4‘-Imino Tautomeric Form of the Coenzyme, Unlike the Michaelis Complex or the Free Coenzyme-Reference-Cited by-同舟云学术

Tetrahedral Intermediates in Thiamin Diphosphate-Dependent Decarboxylations Exist as a 1‘,4‘-Imino Tautomeric Form of the Coenzyme, Unlike the Michaelis Complex or the Free Coenzyme

Published:2004-05-07 Issue:21 Volume:43 Page:6565-6575
ISSN:0006-2960
Container-title:Biochemistry
language:en
Short-container-title:Biochemistry

Author:

Nemeria Natalia¹,Baykal Ahmet¹,Joseph Ebenezer¹,Zhang Sheng¹,Yan ¹,Furey William¹,Jordan Frank¹

Affiliation:

1. Department of Chemistry at Rutgers, the State University, Newark, New Jersey 07102, Biocrystallography Laboratory, Veterans Affairs Medical Center, P.O. Box 12055, University Drive C, Pittsburgh, Pennsylvania 15240, and Department of Pharmacology, University of Pittsburgh School of Medicine, 1340 BSTWR, Pittsburgh, Pennsylvania 15261

Publisher

American Chemical Society (ACS)

Subject

Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/bi049549r

Reference30 articles.

1. Dual Catalytic Apparatus of the Thiamin Diphosphate Coenzyme: Acid−Base via the 1‘,4‘-Iminopyrimidine Tautomer along with Its Electrophilic Role

2. Inhibition of the Escherichia coli Pyruvate Dehydrogenase Complex E1 Subunit and Its Tyrosine 177 Variants by Thiamin 2-Thiazolone and Thiamin 2-Thiothiazolone Diphosphates

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